Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology.

Acta Neuropathol Commun · 2023 · PMC10189946 · PMID 37198698

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Additionally, there was a clear trend towards increased LC3-II and LC3-II/LC3-I levels in pathologically defined preclinical AD (p-preAD) cases, suggesting that autophagy alterations might appear early in the disease progression.

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