Alterations in germinal center formation and B cell activation during severe Orientia tsutsugamushi infection in mice.

PLoS Negl Trop Dis · 2023 · PMC10191367 · PMID 37146079

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highly significantno p-value reported

Among molecules that have known roles in GC B cell survival ( CD40 , ICOS-L , SLAMF1 , CD84 , and IL-21R ) [ 26 , 62 ], their downregulation during Ot infection was highly significant and time dependent.

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showed a trendno p-value reported

Three of these genes, S1PR1 , GPR183 , and CCR7 , showed a trend of continuous downregulation throughout infection, with fold-changes of -1.68, -2.30, and -1.64 at D8, respectively ( Fig 5A ).

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