Loud noise-exposure changes the firing frequency of subtypes of layer 5 pyramidal neurons and Martinotti cells in the mouse auditory cortex.

Examining action potential properties showed no difference in action potential (AP) threshold, although type A PCs showed a trend toward a slightly depolarized AP threshold in cells from noise-exposed animals (ctr A: −46.8 ± 1.8 mV vs. noise A: −42.8 ± 1.2 mV, p = 0.068) while AP threshold was robust for type B PCs from the two groups (ctr B: −41.5 ± 1.9 mV vs. noise B: −42.2 ± 1.7 mV, p = 0.924).

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