showed a trendP = .15
Regression analysis showed a trend to decreased sample sizes from 1990 to 2020 (β = –3.8 [95% CI, 1.4 to –9.0]; P = .15).
Regression analysis showed a trend to decreased sample sizes from 1990 to 2020 (β = –3.8 [95% CI, 1.4 to –9.0]; P = .15).
12 , 13 , 21 – 23 Within the time frame we examined, small sample sizes (<50 patients; n = 75 studies) and a high proportion of single-center trials (86.3%) were observed, and there was a nonsignificant trend toward smaller mean sample sizes over time (see Table 2 ).
The 277 RCTs published in AJSM between 1990 and 2020 demonstrated an increasing trend in the number of trials published over time ( Figure 1 ).