Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system.

PLoS Pathog · 2023 · PMC10194873 · PMID 37155700

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did not reach statistical significanceno p-value reported

In this assay, pre-treatment of P12[HiBiT-CagA] with DARPins K5, K8 and K2 also resulted in a decrease of translocation to comparable levels as in the TEM-1-CagA translocation assay (even though K8 did not reach statistical significance), whereas treatment with K9 did not decrease translocation efficiency ( Fig 5B ).

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