A nanotherapeutic strategy that engages cytotoxic and immunosuppressive activities for the treatment of cancer recurrence following organ transplantation.

Administration of either SN38 or SN38&RAPA dramatically induced apoptosis of Hepa1-6 cells, and SN38&RAPA tended to have a stronger capacity to induce cell apoptosis than SN38, although the difference did not reach statistical significance ( Fig. 3 d and e).

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