SOX2 Promotes Radioresistance in Non-small Cell Lung Cancer by Regulating Tumor Cells Dedifferentiation.

All the results demonstrated that the radioresistant cells showed a trend of dedifferentiation and enhanced expression of stemness characteristics.

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The results showed that the upregulation of SOX2 expression increased the number of sphere-forming cells and significantly improved the sphere-forming ability ( Figure 8 E ), while the number of sphere-forming cells showed a decreasing trend with the silencing of SOX2 expression ( Figure 8 F ).

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