Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank.

Nat Commun · 2023 · PMC10199010 · PMID 37208353

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closest p · 1.0× alpha

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nominally significantp < 0.05actually significant

However, in successive models of Model 3 and 4 (addition of POAG established and suspected risk factors), and Model 5 (further adjust for co-morbidities), we observed that while no metabolite exhibited significance at the NEF < 0.2 level (except for LPC(16:0) in Model 3), all were nominally significant and the direction of associations for the metabolites was similar ( p < 0.05).

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