CSNK2B modulates IRF1 binding to functional DNA elements and promotes basal and agonist-induced antiviral signaling.

Homer was run separately for all nominally significant peaks that were high in CSNK2B siRNA and high in control siRNA with default parameters.

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To determine how altered IRF1-binding affects the basal and agonist-induced transcription in CSNK2B -depleted cells, we conducted quantitative RT-qPCR analysis of genes with promoter occupancy regulated in a highly significant manner ( AFAP1 and DNPEP ) and those involved in antiviral responses ( DDX60L , ELF1 , ERAP2 , HMGB1 , LGALS3BP , MX1 , STAT1 and ZNFX1 ), proviral factors ( AHR , DNAJA1 , SRP54 and TFAP2 ), and immune responses ( DNPEP , PARP14 , SECTM1 , SYNCRIP and TAP2 ) in unstimulated and IFNγ-treated PH5CH8 cells.

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