ERK1/2 phosphorylation at 3 hours of S1P treatment was also decreased with inhibition of S1PR3 in primary hMSMCs, although this did not reach statistical significance in the TL primary hMSMCs ( Fig. 6F and 6I ).
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Sphingosine 1-Phosphate Activates S1PR3 to Induce a Proinflammatory Phenotype in Human Myometrial Cells.
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