Systematic elucidation of genetic mechanisms underlying cholesterol uptake.

Cell Genom · 2023 · PMC10203276 · PMID 37228746

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near-significantno p-value reported

The final library (KO-Library 4) targets 522 genes with significant or near-significant effects on LDL-C uptake from the three previous screens as well as from a published genome-wide LDL-C uptake CRISPR-Cas9 screen performed in Huh7 cells. 22 Altogether, the four screens identify a total of 490 genes whose knockout alters LDL-C uptake under either SER or SS conditions (299 decrease u

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