Bioactive lipid lysophosphatidic acid species are associated with disease progression in idiopathic pulmonary fibrosis.

J Lipid Res · 2023 · PMC10205439 · PMID 37075981

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In a phase 2a study in patients with IPF, ATX inhibitor reduced plasma LPA18:2 levels by at least 50% over 12 weeks, and the reduction was accompanied by forced vital capacity (FVC) stabilization in the treated group while the placebo group showed a trend of FVC decline ( 15 ).

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