Second, a significant trend towards lower C1GALT1 expression in high grade tumors was also evident, in spite of this association being less obvious and non-significant when analyzing endometrioid tumors independently.
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In-depth quantitative proteomics analysis revealed C1GALT1 depletion in ECC-1 cells mimics an aggressive endometrial cancer phenotype observed in cancer patients with low C1GALT1 expression.
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