Statistical inference reveals the role of length, GC content, and local sequence in V(D)J nucleotide trimming.

There, researchers have found quite significant connections between local sequence identity and mutation patterns, leading to a rich literature ( Rogozin and Kolchanov, 1992 ; Dunn-Walters et al., 1998 ; Cohen et al., 2011 ; Yaari et al., 2013 ; Elhanati et al., 2015 ; Wei et al., 2015 ; Cui et al., 2016 ; Feng et al., 2019 ; Spisak et al., 2020 ).

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