Even though only significant in the miR-132 KD experiment, Trem2 , another critical risk factor for AD and key modulator of microglial function, 100 , 101 , 102 showed a trend for anticorrelation to miR-132 levels upon both overexpression and knockdown of miR-132 ( Table S3 ).
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microRNA-132 regulates gene expression programs involved in microglial homeostasis.
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