PD-1 blockade potentiates neoadjuvant chemotherapy in NSCLC via increasing CD127⁺ and KLRG1⁺ CD8 T cells.

The density of TLSs showed the higher trend in post-NAPC than in post-NAC, although it did not reach statistical significance due to the higher necrosis rate of pCR patients in post-NAPC (Fig. 5a, b ; P = 0.3064).

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The spatial distribution of CD8 + T and CD8 + CD127 + T cells with CD4 + T/CD20 + B cells showed an elevated trend in MPR patients in both NAC and NAPC, whereas CD8 + KLRG1 + T cells exhibited an elevated trend in non-MPR patients in the NAPC group (Supplementary Fig. 8a–f ), which requires a larger cohort to verify.

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