A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.

Front Aging Neurosci · 2023 · PMC10213779 · PMID 37251807

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0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

a strong trendp = 0.054so close (0.05 < p ≤ 0.1)

However, pyruvate and butyrate showed a strong trend for reduced SRC (ANOVA p = 0.054, 0.082 respectively), less so for succinate (0.134) as the data were variable.

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