Apparent Opportunities and Hidden Pitfalls: The Conflicting Results of Restoring NRF2-Regulated Redox Metabolism in Friedreich's Ataxia Pre-Clinical Models and Clinical Trials.

Biomedicines · 2023 · PMC10215444 · PMID 37238963

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did not reach statistical significanceno p-value reported

While the first treatment modality determined a slight increase of FXN mRNA and mitobiogenesis (as measured by mitochondrial DNA/nuclear DNA ratio), which did not reach statistical significance and yielded no improvement in behavioural tests, the second determined an improvement of motor function as assessed by rotarod performance test [ 123 ].

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