Benefit of Early Ruxolitinib Initiation Regardless of Fibrosis Grade in Patients with Primary Myelofibrosis: A Post Hoc Analysis of the Single-Arm Phase 3b JUMP Study.

A clear trend between fibrosis grade and spleen response rate was observed for patients achieving a spleen response at Week 24 or at any time during the study, with response rates decreasing with increasing fibrosis grade ( Figure 1 B).

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