Difference in Efficacy and Safety of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy Containing 4-1BB and CD28 Co-Stimulatory Domains for B-Cell Acute Lymphoblastic Leukemia.

The results showed a trend towards a higher ORR in children than in adults, with 86.59% and 76.32%, respectively, a trend towards a higher ORR in the low morphologic relapse population than in the high morphologic recurrence relapse population, with 85.54% and 74.08%, respectively, and a trend towards a lower incidence of CRS and neurotoxicity in allogeneic T-cells than in autologous T-cells, with 72.00% vs. 88.66% and 41.4% vs. 21.47%, respectively; however, none of these results showed a significant difference because their 95% CIs mostly overlapped. 3.5.

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