Glycine-β-Muricholic Acid Improves Liver Fibrosis and Gut Barrier Function by Reducing Bile Acid Pool Size and Hydrophobicity in Male <i>Cyp2c70</i> Knockout Mice.

The mRNA of chemokine monocyte chemoattractant protein-1 (MCP-1) and fibrosis genes collagen 1A1 (COL1A1) trended lower but did not reach statistical significance, and metallopeptidase inhibitor 1 (TIMP1) was significantly reduced in the G-β-MCA treatment group ( Figure 2 D–F), which was consistent with the reduction in liver fibrosis in G-β-MCA-treated mice ( Figure 1 H–J). 3.2.

also in 111,027 other papers