Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates.

Cells · 2023 · PMC10216823 · PMID 37408256

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0880

boldest claim

The sentences

borderline significancep = 0.056so close (0.05 < p ≤ 0.1)

Additionally, the pTAU-positive area decreased with borderline significance in conjugate-treated slices ( Figure 4 c, treatment, p = 0.056).

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showed a trendp = 0.076so close (0.05 < p ≤ 0.1)

However, the NP-B6 conjugate-treated P301S slice culture samples showed a trend towards increased levels of hTAU as compared to the slice cultures receiving other NP treatments ( Figure 5 f, p = 0.076), implicating that some pTAU might have been caught with B6 and pulled into the magnetic fraction by conjugated iron-cored NP using magnetic separation.

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a decreasing trendp = 0.088so close (0.05 < p ≤ 0.1)

Consistent with the results from experiment 1, the B6 antibody and PEG-coated nanoparticle-B6-conjugate showed a decreasing trend in the integrated density of pTAU in the treated slices ( Figure 4 f, p = 0.088, experiment 2).

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