Microphthalmia-Associated Transcription Factor: A Differentiation Marker in Uveal Melanoma.

Moreover, the HLA-DR score for UM with no-low pigmentation was lower than in moderately pigmented and heavily pigmented UM, even though the latter comparison did not reach statistical significance (no-low vs. moderate pigmentation: p = 0.027, no-low vs. heavy pigmentation: p = 0.053) ( Supplementary Figure S1e ).

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Table 1 also shows that MITF expression was higher in UM with chromosome 6p gain, which was associated with a better prognosis, albeit with a borderline significance ( p = 0.049).

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Further evidence that chromosome 3 status may not be the only determinant of MITF expression is provided in Figure 1 c: when considering both chromosome 3 and 8q status, we can see a decreasing trend in MITF expression from D3 with normal 8q to D3 with 8q gain to M3.

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