Metformin and Canagliflozin Are Equally Renoprotective in Diabetic Kidney Disease but Have No Synergistic Effect.

Int J Mol Sci · 2023 · PMC10219450 · PMID 37240387

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In line with the Masson Trichrome-stained sections of the DKD rats, metformin-treated (alone or in combination with canagliflozin) animals showed a trend towards a diminished expression of the fibrotic gene, transforming growth factor β (Tgfβ) ( Figure 7 A), though this trend did not reach significance.

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