Altered parabrachial nucleus nociceptive processing may underlie central pain in Parkinson's disease.

Statistical analysis comparing Sham and DA lesioned rats showed a main effect of the lesion on PSD thickness (Mean ± SEM Sham = 43.84 ± 1.49 nm; Partial = 34.53 ± 1.13 nm; Total = 37.49 ± 1.25 nm; KW[2, 357] = 28.18; p < 0.0001) and a strong trend toward an effect on PSD length (Mean ± SEM Sham = 427.30 ± 17.75 nm; Partial = 372.20 ± 14.52 nm; Total = 396.10 ± 15.84 nm; KW[2, 357] = 5.73; p = 0.05).

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