Novel Adjuvant S-540956 Targets Lymph Nodes and Reduces Genital Recurrences and Vaginal Shedding of HSV-2 DNA When Administered with HSV-2 Glycoprotein D as a Therapeutic Vaccine in Guinea Pigs.

S-540956 induced the most potent gD2-specific CD8 + IFNγ + response at a concentration of 26 nmol, which was significantly higher than in the PBS control ( Figure 1 F and Figure S1 ), and despite being greater than gD2 alone or gD2 with 26 nmol ODN2006, those differences did not reach statistical significance ( Figure 1 F).

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