Balancing Functional Tradeoffs between Protein Stability and ACE2 Binding in the SARS-CoV-2 Omicron BA.2, BA.2.75 and XBB Lineages: Dynamics-Based Network Models Reveal Epistatic Effects Modulating Compensatory Dynamic and Energetic Changes.

Viruses · 2023 · PMC10221141 · PMID 37243229

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a clear trendno p-value reported

Another important implication of the network community analysis is a clear trend showing the increased density and spatial “expansion” of the stable RBD communities in the BA.2.75 and especially XBB.1.5 complexes ( Figure 7 ).

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