Adherence to Overactive Bladder Syndrome Treatments Recent Developments and Future Perspectives.

The mean OAB-S Medication Tolerability score of 83.40 for tolterodine (CI: 80.59, 86.20) was significantly lower than 86.29 for mirabegron (CI: 83.50, 89.08; p < 0.004) and because the “period-by-treatment” interaction did not reach statistical significance (p=0.955), the possibility of tolerability scores being affected by medication sequence was excluded.

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46 studies, comprising 60,944 participants, were included in a systematic review, which demonstrated an association between increasing anticholinergic load and decline in cognition, and although not statistically significant, an increasing trend in mortality. 30 Similar results were reported in a longitudinal study of 13,004 participants over the age of 65 years taking anticholinergic medication for two years. 2-year mortality risk was increased (OR = 1.68; 95% CI: 1.30–2.16; p<0.001) and Mini Mental State Examination (MMSE) scores signifi

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