Barely Significant
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Erratum: Addendum and Corrigendum to "Subclinical cardiovascular disease and utility of coronary artery calcium score" [IJC Heart Vasculat. 37 (2021) 100909].

Int J Cardiol Heart Vasc · 2023 · PMC10225660 · PMID 37255860

4
hedged sentences
0.0500
closest p · 1.0× alpha
0.0530
boldest claim

The sentences

nominally significantp < 0.05actually significant
Studies) below Metabolome Wide Significance Level (MWASL) threshold (p = 2.4 * 10E–9 to 1.1 * 10E–5) with Ln[CACs + 1] mannose, alanine and acetaminophen-glucuronide strongly associated yet glutamate and histidine had strong inverse associations besides other significant metabolites also remained nominally significant (p < 0.05) but by 50% weaker association; furthermore, lipoprotein subcategories of total plasma cholesterol, total plasma apolipoprotein B and apolipoprotein B within total plasma LDL significantly associated with Ln[CACs + 1] in model-3 (further adjusted for model-1 + nonlipid CVD risk factors of SBP, DM, Smoking status, and use of medication for hypercholesterolemia, BP or DM).”.

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borderline significancep = 0.053so close (0.05 < p ≤ 0.1)
tolic dysfunction) significantly associated with lower HDL-c, eIS (estimated-Insulin sensitivity) and adiponectin levels besides higher TNF-α and Leptin levels; nonetheless, both VAT ≥ 100 vs <100 and Diastolic dysfunction presence vs absence significantly associated with higher insulin level (yet borderline significance for patients with diastolic dysfunction, p = 0.053) and rate of having CACs ≥ 10; moreover, only CACs ≥ 10 vs <10 (not VAT ≥ 100 or Diastolic dysfunction) significantly associated with higher levels of LDL-c, rates of macrovascular abnormalities of carotid artery plaques and wall-motion abnormalitie

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borderline significantno p-value reported
no significant association between NAFLD and either CACs > 0 or CACs categories even for crude models, and comparably females (n = 1310) had more significant trends and associations, in which for association of higher CACs > 0 prevalence remained significant till model-3 adjustment (OR:1.568) and borderline significant for model-4, and for CACs categories remained significant even after model-4 adjustment (OR:1.526), moreover, among female subjects postmenopausal (n = 802) vs. premenopausal (n = 508) patients had significantly higher levels of BMI, abdominal circumference, hip circumference, TG, TC and LDL-c, and higher prevalence of DM, HTN, Hyperlipidemia, NAFLD and any CACs > 0.

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marginally significantno p-value reported
vs CACs = 0 and BMI ≥ 25 kg/m 2 (OR:1.884), eGFR < 90 mL/min/1.73 m2 (OR:2.699), Fatty liver index (OR:1.019) and APRI (>0.219; OR:2.843) had significant association for CACs > 100 vs CACs = 0, furthermore, in multivariate binary logistic regression analysis, which was derived from significant or marginally significant conventional risk factors for CACs > 100 by univariate analysis, for CACs > 100 remained significant with Age > 55 years (OR:4.809), BMI ≥ 25 kg/m 2 (OR:2.072) and eGFR < 90 mL/min/1.73 m2 (OR:2.149), and in multi-variate analysis adjusted by these 3 risk factors (besides gender) for the association

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