nominally significantp < 0.05
Studies) below Metabolome Wide Significance Level (MWASL) threshold (p = 2.4 * 10E–9 to 1.1 * 10E–5) with Ln[CACs + 1] mannose, alanine and acetaminophen-glucuronide strongly associated yet glutamate and histidine had strong inverse associations besides other significant metabolites also remained nominally significant (p < 0.05) but by 50% weaker association; furthermore, lipoprotein subcategories of total plasma cholesterol, total plasma apolipoprotein B and apolipoprotein B within total plasma LDL significantly associated with Ln[CACs + 1] in model-3 (further adjusted for model-1 + nonlipid CVD risk factors of SBP, DM, Smoking status, and use of medication for hypercholesterolemia, BP or DM).”.