Macitentan for the Treatment of Refractory Digital Ulcers in Patients With Connective Tissue Diseases.

Cureus · 2023 · PMC10226674 · PMID 37255911

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

did not reach statistical significanceno p-value reported

However, two clinical trials did not reach statistical significance in terms of efficacy in preventing new DUs, although there are case reports that have demonstrated its efficacy, even in some of the patients included in the DUAL-2 trial [ 18 - 20 ].

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.