Acquired DNA damage repairs deficiency-driven immune evolution and involved immune factors of local versus distant metastases in non-small cell lung cancer.

For specific DDR pathways, the difference of CCF increase was significant in the Fanconi anemia pathway ( P = 0.007) and showed trend toward significance in HRR pathway ( P = 0.18) ( Figure 1D ).

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Analysis of TCGA data and a single-cell RNA-sequencing dataset revealed a decreasing trend of major immune cells, such as CD8+ T cells, and an increasing trend of CD4 T helper cells (Th2 and Th1) in primary tumors with metastases from local to distant sites.

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Analysis of TCGA data and a single-cell RNA-sequencing dataset revealed a decreasing trend of major immune cells, such as CD8+ T cells, and an increasing trend of CD4 T helper cells (Th2 and Th1) in primary tumors with metastases from local to distant sites.

also in 19,102 other papers

BRCA1 , BRCA2 , FANCA and ATR gene, which showed a trend of being enriched in metastases, are members of the Fanconi anemia pathway (Supplementary Table S3).

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