Dendritic cell therapy augments antitumor immunity triggered by CDK4/6 inhibition and immune checkpoint blockade by unleashing systemic CD4 T-cell responses.

Gene Ontology (GO) analysis revealed a highly significant enrichment of GO terms related to cell proliferation, such as ‘cell cycle’, ‘cell division’, and ‘mitotic nuclear division’, among palbociclib-downregulated genes ( figure 1D ).

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Notably, triple therapy increased the proportion of Tbet hi and Eomes hi CD4 T (Th1) cells and the levels of Tbet expression per cell in the TME and periphery, although the difference did not reach statistical significance in the TME ( figure 7E F and online supplemental figure S13E, F ).

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