The host-directed therapeutic imatinib mesylate accelerates immune responses to Mycobacterium marinum infection and limits pathology associated with granulomas.

In the RNAseq analysis, infection increased levels of tnf at the one week timepoint, an effect slightly augmented by imatinib, and levels increased further by three weeks, though these differences did not reach statistical significance at the p<0.05 level ( Fig 5B ).

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