Combination of AFP vaccine and immune checkpoint inhibitors slows hepatocellular carcinoma progression in preclinical models.

Furthermore, in silico cell deconvolution using the ImmuCC algorithm ( 17 ) predicted a strong trend toward increased CD8 + T cells in tumors from the AFP immunized mice ( Supplemental Figure 6 , E and F), in line with the flow cytometry and IHC data ( Supplemental Figure 1 and Figure 2, D–F ).

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