Silencing miR-21-5p in sensory neurons reverses neuropathic allodynia via activation of TGF-β-related pathway in macrophages.

In keeping with the possibility that TGF-β pathway–related changes occur in macrophages 7 days after SNI, F4/80 + cells from miR-21–cKO ipsilateral DRGs showed a trend toward higher TGF-βR2 + events and substantially higher TGF-βR2 expression at the cellular level compared with WT ( Figure 4, F and G ).

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