We observed (i) an association between anti-CCP2 positivity at RA diagnosis and VTE risk, including a clear trend towards higher VTE risks with higher IgG CCP2 levels, (ii) an (at least) equally strong association between the number of ACPA fine-specificities and VTE risk, (iii) no specific association with anti-Cit-Fib antibodies or with AMPA targeting carbamylated or acetylated antigens, (iv) an association between IgM RF and VTE risk, and (v) that none of the associations were readily explained by smoking or the HLA-DRB1 shared epitope.
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The association between autoantibodies and risk for venous thromboembolic events among patients with rheumatoid arthritis.
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