Longitudinal transcriptomic analysis of mouse sciatic nerve reveals pathways associated with age-related muscle pathology.

J Cachexia Sarcopenia Muscle · 2023 · PMC10235898 · PMID 36905126

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.1000

boldest claim

The sentences

did not reach statistical significanceP = 0.06so close (0.05 < p ≤ 0.1)

In the quadriceps, there was an increase in percentage of myofibers with centralized nuclei that did not reach statistical significance ( P = 0.06).

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marginally significantP < 0.1so close (0.05 < p ≤ 0.1)

5 We observed significantly increased expression in Chrnd and Runx1 at 24 months compared with 5‐month‐old mice ( P = 0.013 and 0.045, respectively) and a marginally significant increase ( P < 0.1) in expression of Gadd45ɑ comparing 24‐month‐old mice with 5‐month‐old mice ( P = 0.088) ( Figure S6 ).

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borderline significantno p-value reported

‘Circadian rhythm’ was also a significant GO Biological Process (BP) term (FDR q ‐value = 7.8E‐4) of the 54 up‐regulated genes with FDR < 0.1 and was borderline significant (FDR q ‐value = 0.055) for the 28 DEGs with FDR < 0.05.

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