Dasatinib-induced spleen contraction leads to transient lymphocytosis.

Already starting with the first dose of dasatinib, spleens showed a trend toward smaller sizes, and this trend became statistically significant after the third dose ( Figure 3 B).

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A parallel ultrasound analysis of spleen uncovered a significant decrease of the 3 axis’ (caudal, transverse, and anteroposterior) lengths after dasatinib treatment in most patients, which translated into a highly significant decrease in the total volume ( Figure 5 B).

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We also observed a nonsignificant trend in augmented circulating neutrophils, monocytes, and NK cell numbers, in line with previous observations. 9 In specific-pathogen-free (SPF) facility–housed C57BL/6 mice, most circulating lymphocytes display a naïve (CD62L + CCR7 + CD44 low ) phenotype and use the lymph and blood circulation systems to traffic between distinct SLOs. 33 We hypothesized that dasatinib-treated lymphocytosis might stem from either an impaired trafficking of blood-borne lymphocytes to SLOs, leading to their accumulation in blood, and/or an increased egress from SLOs.

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