Lyophilization to enable distribution of ChAdOx1 and ChAdOx2 adenovirus-vectored vaccines without refrigeration.

NPJ Vaccines · 2023 · PMC10240132 · PMID 37277337

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quite significantno p-value reported

We observed quite significant in-process loss and run-to-run variation: 75–90% of the infectious titre of the product was lost during the lyophilization process, and stability was insufficient for long-term storage in an uncontrolled environment 8 .

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