30 – 32 However, the large Tiotropium Safety and Performance in Respimat (TIOSPIR) study 33 and the results of real-life research 34 showed that tiotropium, when administered by Respimat, was not less safe than Handihaler, although it showed a trend toward an increased incidence of myocardial infarction.
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Cardiovascular diseases or type 2 diabetes mellitus and chronic airway diseases: mutual pharmacological interferences.
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