Morphological and sensorimotor phenotypes in a zebrafish CHARGE syndrome model are domain-dependent.

That both chromodomain and ATP‐helicase domain mutants show significantly reduced LLC responses when the genetic background is at least 50% TLF while chd7 ncu101//rdu1002 double heterozygotes only showed a trend indicates that there could be differential functional capacity of the two chd7 alleles and/or that modifiers in the genetic background may influence the expression of the defect. 3.3. chd7 alleles produce varying visual and general locomotor phenotypes Visual deficits are common in CHARGE patients, 47 , 48 and therefore we assessed visual responsiveness of chromodomain chd7 mutants with multiple assays.

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