Association of Extubation Failure Rates With High-Flow Nasal Cannula, Continuous Positive Airway Pressure, and Bilevel Positive Airway Pressure vs Conventional Oxygen Therapy in Infants and Young Children: A Systematic Review and Network Meta-Analysis.

JAMA Pediatr · 2023 · PMC10242512 · PMID 37273226

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a nonsignificant trendno p-value reported

Compared to HFNC, CPAP (OR, 2.7; 95% CrI, 0.84-13) and BiPAP (OR, 3.1; 95% CrI, 0.80-20) had a nonsignificant trend for increased incidence of nasal injury (eTable 7 in Supplement 1 ).

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close to the level of significanceno p-value reported

The 95% CrI of the interaction coefficient for TF was close to the level of significance, suggesting that all 3 interventions (HFNC, CPAP, and BiPAP) may be more effective than COT in infants.

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