Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity.

Similarly, for donors in classes C–E (for whom information about obesity and diabetes was available), only CD177 and CD89 exhibited weakly significant variation with obesity (p = 0.043 in each case) and no markers varied significantly in the presence or absence of diabetes ( Table S6 ).

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Notably, we observed highly significant enrichment of terms related to microbial defense among cellular proteins upregulated during severe disease.

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