In males, a trend toward earlier age of preputial separation was observed in Mkrn3 KO compared with Mkrn3 WT animals, though it did not reach statistical significance ( t 18 = 1.750, P = 0.097, Figure 3, H and I ).
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MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity.
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0.0970
0.0970