Lipoprotein(a) induces caspase-1 activation and IL-1 signaling in human macrophages.

Front Cardiovasc Med · 2023 · PMC10244518 · PMID 37293282

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a slight trendno p-value reported

In the stimulation with plasmas containing Lp(a) we observed a slight trend towards increased expression of IL-8 but note the variability in the response to different plasmas, that may have obscured an increase.

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showed a trendno p-value reported

In PBMC-derived macrophages, incubation with the recombinant proteins showed a trend towards induction of caspase-1 activity, but little to no effect on IL-1β or IL-18 secretion.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.