Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach.

Added value of this study Our exploratory study on the dynamic changes in the urinary metabolome of asphyctic newborns undergoing therapeutic hypothermia in their first three days of life showed that steroidogenesis was the most deranged pathway; the novelty of our work is that we showed that patients’ urinary steroid levels were lower than in healthy matched newborns, and showed a clear trend towards steady decrease over time.

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