Comparative evaluation of clinical and cerebrospinal fluid biomarker characteristics in rapidly and non-rapidly progressive Alzheimer's disease.

The Tau/Aβ1-42 ratio (rpAD, median: 1.32, IQR = 1.07; non-rpAD, median: 0.75, IQR = 0.77) and the p-Tau/Aβ1-42-ratio (rpAD, median: 0.18, IQR = 0.18; AD, median: 0.14, IQR = 0.13) were higher in the rpAD group, which turned out to be highly significant in exploratory comparisons (Tau/Aß1-42: p < 0.001; p-Tau/Aβ1-42: p = 0.007) as well as in corrected regression models (Tau/Aβ1-42: p = 0.004; p-Tau/Aβ1-42: p = 0.004).

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In this study, medians of p-Tau (rpAD: 85.5 pg/ml; non-rpAD: 77 pg/ml) and the p-Tau/Tau ratio (rpAD, median: 0.16; AD, median: 0.17) showed no significant differences but a clear trend towards higher levels of p-Tau in rpAD.

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