A crucial role for dynamic expression of components encoding the negative arm of the circadian clock.

A clear trend of period lengthening effects was observed in WT in the presence of 1–100 μM AZD4573, while ∆ brd-8 shows even a stronger dose effect on period changes than WT, especially 100 μM at which concentration ∆ brd-8 becomes completely arrhythmic, while WT is ~ 6 h longer than seen under no drug treatment (Fig. 7a ).

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