Pan-cancer analysis of TASL: a novel immune infiltration-related biomarker for tumor prognosis and immunotherapy response prediction.

To investigate the degree of immune cell infiltration at the tumor site in the two subgroups of patients, we further explored the relationship between TIL fraction (estimated by T cell receptor sequencing (TCR-seq)) and TASL expression in the tumors of both groups of patients and found that in the NA-aPD1 group, there was a positive trend of correlation between TIL fraction and TASL expression ( R = 0.539, P = 0.061), whereas in the A-aPD1 group, TIL fraction was not associated with TASL expression ( R = -0.164, P = 0.555, Fig. 4 F), implying that in the NA-aPD1 subgroup, high TASL expression may be positively correlated with the activation of adaptive immunity.

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Interestingly, we noticed that the high expression tends to correlate with longer OS and larger TIL fraction (this did not reach statistical significance, probably due to the small sample size) in the neoadjuvant anti-PD-1 with postoperative adjuvant anti-PD-1 (NA-aPD1) subgroup in analyzing the “cold” tumor GBM dataset GSE121810 .

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