Since the survival of mice in the Tfh-depletion group in our study did not reach statistical significance, it stands to reason that other CD4+ Th cells subsets may permit EBV–infected B-cells survival in SCID mice as CD4+ Th cells are more plastic and play dual roles [ 67 ].
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Follicular Helper and Regulatory T Cells Drive the Development of Spontaneous Epstein-Barr Virus Lymphoproliferative Disorder.
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